This article shows the fact that A1 adenosine receptors are present in the smooth muscle cells of the afferent arteriole (AA).
The tubuloglomerular feedback (TGF) response involves the vasoconstriction of the AA as a response to increased glomerular filtration rate (which leads increased sodium chloride at the tubular level of the macula densa (MD).
Vasoconstricting the AA, lowers the GFR.
Credits
Renal Corpuscle Image. 2019. Downloaded under a Creative Commons Attribution-Share Alike 4.0 International License from Wikimedia Commons. Author: Shypoetess. No changes were made.
Posts in this series
The Macula Densa Cells May Sense Tubular Salt Content Using a NHE2 Exchanger
The Macula Densa Cells Also Can Sense Sodium and Chloride Concentrations Using the NKCC2 Transporter
MAP Kinases are Activated by Low Tubular NaCl and Stimulate COX-2 Expression
Inhibition of nNOS in the Macula Densa leads to an Exaggerated TGF Response
The Juxtaglomerular Granular Cells are More Numerous in the Afferent Arteriole
Angiotensin II, Mediated by AT1 Receptors, Stimulates Nitric Oxide Release in Afferent Arterioles
Angiotensin II Effects are Different in the Afferent and Efferent Arterioles
Macula Densa Cell Depolarization Mediates Release of ATP When There is Increase in Sodium Chloride
The Extraglomerular Mesangial Cells Participate in the Signaling of the TGF
ATP is Released Through Large Channels at the Basolateral Membrane of the Macula Densa Cells