This article shows that the EP4 receptor for PGE2 in the juxtaglomerular (JG) granular cell is the main one necessary for signaling the production of renin.

The stimulation of the EP4 receptor by an agonist leads to a rapid cAMP formation in the JG granular cell and subsequent renin secretion.

It is also known that the activation of renin activity by furosemide is dependant on the EP4 receptor.

Renin will cleave angiotensinogen and release angiotensin I, which will be converted in to angiotensin II and will constrict the efferent arteriole.

Credits

Renal Corpuscle Image. 2019. Downloaded under a Creative Commons Attribution-Share Alike 4.0 International License from Wikimedia Commons. Author: Shypoetess. No changes were made.

Posts in this series

1. Overview

2. Overview (cont)

3. The Macula Densa Cells May Sense Tubular Salt Content Using a NHE2 Exchanger

4. The Macula Densa Cells Also Can Sense Sodium and Chloride Concentrations Using the NKCC2 Transporter

5. PGE2 Inhibits nNOS in the Macula Densa Cells

6. MAP Kinases are Activated by Low Tubular NaCl and Stimulate COX-2 Expression

7. Inhibition of nNOS in the Macula Densa leads to an Exaggerated TGF Response