- In Super Smash Bros. Brawl, Ivysaur is the only Pokémon that Pokémon Trainer uses that does not use an HM move. Squirtle uses Waterfall, while Charizard uses Rock Smash and Fly.
- Ivysaur's numbers in the National Pokédex and the Fiore Browser are the same: 002.
- Ivysaur is the only second stage Grass/Poison Pokémon that does not require an evolutionary stone to reach its final form.
- Ivysaur is the only second stage form of Generation I starter Pokémon that evolves at level 32. Charmeleon and Wartortle evolve at level 36.
- Due to the censor that prevents Pokémon with offensive nicknames being traded on the GTS, an Ivysaur with an English name cannot be traded on the GTS without a nickname in Pokémon Black and White.