This article is a review of the pathogenesis of pigment nephropathy, mediated by the inflammasome pathway. In essence, the filtered hem groups can trigger an inflammatory response when reabsorbed by the proximal tubular cells, which may leads to the tubular necrosis seen in rhabdomyolysis, for example

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To quote this article in bibliography using Chicago style :

Giuliani, Kurt, Andrew J. Kassianos , Helen Healy, Pedro H. F. Gois. “Pigment Nephropathy: Novel Insights into Inflammasome-Mediated Pathogenesis." International Journal of Molecular Sciences 20, no. 8 (2019): 1-17. https://doi.org/10.3390/ijms20081997

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