This article is a review of the mechanisms known to explain the diuretic effect of caffeine.

• Caffeine inhibits the vasoconstriction mediated by the type 1 adenosine receptor in afferent arteriole increasing the glomerular filtration rate (GFR). This is the mediator of the tubuloglomerular feedback (TGF).

• Caffeine inhibits the reabsorption of sodium at the level of the renal proximal tubule.

• Caffeine affects the hepatorenal reflex by antagonizing the effect of adenosine in the Mall spaces of the liver and releasing the antidiuretic effect via the nervous system

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To quote this article in bibliography using Chicago style :

Marx, Barbara, Éléonore Scuvée, Jacqueline Scuvée-Moreau, Vincent Seutin et François Jouret. “ Mechanisms of caffeine-induced diuresis." Medecine/Science 32, no. 5 (2016): 485-490. https://doi.org/10.1051/medsci/20163205015.

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