Tuberculosis is managed by the following drugs usually in combination to prevent mycobacterium resistance and toxicity
oRifampicin symbolized by R
oIsoniazid symbolized by H
oPyrazinamide symbolized by Z
oEthambutol symbolized by E
![Screenshot_3.png]oStreptomycin symbolized by S
Tuberculosis is usually managed in two phases, initial phases and continuous phase
oThe initial phase; during this phase combination drugs are continued for 2 months
oDrugs used in initial phase are
rifampicin,
isoniazid,
pyrazinamide and
ethambutol
oThese drugs should be continued until full susceptibility is confirmed, even if this is for longer than 2 months
oContinuation phase; after the initial phase, treatment is continued for a further 4 months with
isoniazid and
rifampicin (preferably given as a combination preparation). Longer treatment is necessary for meningitis, direct spinal cord involvement, and for resistant organisms which may also require modification of the regimen
Other drugs indicated for management of tuberculosis as second line include
cycloserine,
ethionamide and
streptomycin
(
)