One of the biggest contributors to the anti-cannabis effort here in AZ back in 2016 (to the tune of $500,000) was Insys Pharmaceuticals who produced Fentanyl and (surprise, surprise) were developing a synthetic THC. They've been busted big time recently but probably were the big reason recreational cannabis wasn't legalized here.
RE: Entourage Effect(A Brief Summary On Cannabanoids & Terpenes)