English vocal-and-synth duo Soft Cell became aware of the song through its status as a UK "Northern Soul" hit, and recorded a drastically different arrangement in 1981. The Soft Cell recording featured a slower tempo than Jones' version, and was in the key of G rather than the original C to match Marc Almond's lower voice. Synthesizers and rhythm machines replaced the original's guitars, bass, drums, and horns. Soft Cell's version was recorded in a day and a half with Almond's first vocal take being used on the record. Producer Mike Thorne commented that he was surprised by the choice as he had not been impressed by the 1976 version on hearing it, but was impressed by the new arrangement and Almond's sinister vocal: "You could smell the coke on that second, Northern Soul version, it was really so over-ramped and so frantic. It was good for the dance floor, but I didn't like the record...when Soft Cell performed the song I heard a very novel sound and a very nice voice, so off we went."
The band's record label[clarification needed] chose to release "Tainted Love" on July 7, 1981 as Soft Cell's second single (their first was "Memorabilia", which did not chart). The Phonogram Records representatives implied that this single would be Soft Cell's final release on Some Bizzare if the single did not sell. The 12" single version (extended dance version) was a medley, transitioning to a cover of the Supremes' "Where Did Our Love Go" halfway through the song. Buoyed by the then-dominant synthpop sound of the time and a memorable performance on Top of the Pops, "Tainted Love" rapidly reached number 1 on the UK singles chart. "Tainted Love" was the best-selling single of 1981 in the UK and has sold 1.35 million copies as of August 2017.
On the US chart dated January 16, 1982, the song entered the Billboard Hot 100 at number 90. It appeared to peak at number 64 and fell to number 100 on February 27. After spending a second week at number 100, it started climbing again. It took 19 weeks to crack the US Top 40. The song reached number 8 during the summer of 1982 and spent a then record-breaking 43 weeks on the Hot 100.
A video was recorded specially for Soft Cell's video album Non-Stop Exotic Video Show featuring band members David Ball as a cricketer meeting Marc Almond in a toga on Mount Olympus.
A remixed version of the song was issued in 1991, seven years after Soft Cell's dissolution in 1984. The video for the remix, directed by Peter Christopherson of Hipgnosis, features a man pacing at night and dancing with starry apparitions, while Almond sings amongst the stars. Christopherson's band Coil had covered "Tainted Love" in 1985, with a music video that included a cameo appearance by Almond.
Soft Cell's version of "Tainted Love" ranked number 5 on VH1's 100 Greatest One Hit Wonders of the 1980s. It was also heavily sampled on Rihanna's 2006 single "SOS" and the Veronicas's 2007 single "Hook Me Up". In 2015 the song was voted by the British public as the nation's fourth favourite 1980s number one in a poll for ITV.
