Trimethylglycine
C5H11NO2

Inositol Niacinate
C42H30N6O12

Trigonelline
C7H7NO2

Trigonellinamide
C7H9N2O+

Nicotinamide
C6H6N2O

Niacin
C6H5NO2

..

Trigonelline (TRL)
Trimethylglycine (TMG)
Trigonellinamide (MNA)
Trimethylamine (TMAO)
Dimethylsulfoxide (DMSO)

+1 Nitrogen Charge:

Trimethylglycine
Trigonellinamide
Trigonelline

Nucleotide
Salvage Pathway

MNA
Methylnicotinamide
Trigonellamide

Niacin
Betaine
DMSO/MSM

..

N1-methylnicotinamide (Trigonellinamide) can be found abbreviated as MNA, meNAM, MNAM, or even NMN, creating inconsistency and confusion in the literature.

..

SAMe
DAO
CoA

luteolin content. Scientists studying the effects of this polyphenol founds that it entirely abolished skin flushing (and entirely abolished the rise in serum Prostaglandin D2) in humans taking Niacin.

DAO, an enzyme that depends on Vitamin C, copper and magnesium, and via HNMT, which requires methylation).

nicotinic acid, inositol hexaniacinate and niacinamide.

..

Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

https://www.nature.com/articles/s42255-024-00997-x

Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30190-X

..

S-adenosyl-l-homocysteine (SAH)

CD38 Inhibitor 1

NNMT
CD38
PARP
Sirtuin
MTHFR

Trimethylamine
Trimethylamine N-Oxide

https://en.m.wikipedia.org/wiki/NNMT

https://en.m.wikipedia.org/wiki/CD38

https://en.m.wikipedia.org/wiki/CD38-IN-78c

https://en.m.wikipedia.org/wiki/Nucleotide_salvage

..

Complex roles of nicotinamide N-methyltransferase in cancer progression

https://www.nature.com/articles/s41419-022-04713-z

Nicotinamide N-methyltransferase (NNMT) is an S-adenosyl-l-methionine (SAM)-dependent cytosolic enzyme. Taking SAM as the methyl donor, NNMT catalyzes N-methylation of nicotinamide (NAM) to generate 1-methylnicotinamide (1-MNAM) and S-adenosyl-l-homocysteine (SAH).

..

https://en.m.wikipedia.org/wiki/Trimethylamine

https://en.m.wikipedia.org/wiki/Trimethylamine_N-oxide

..

DMSO and TMAO
Differences in Interactions in Aqueous Solutions of the K-Peptide

https://pmc.ncbi.nlm.nih.gov/articles/PMC8836737/