Xylazine
Zombie Drug

Since xylazine is not an opioid, it is not neutralized by naloxone (Narcan). However, experts still recommend administering naloxone during a suspected xylazine overdose because the drug is very frequently mixed with opioids like fentanyl.

the alpha-2 antagonist atipamezole was used to reverse the effects of xylazine or the related drug dexmedetomidine

the effects of xylazine in animals were also reversed by the analeptics 4-aminopyridine, doxapram, and caffeine, which are physiological antagonists to central nervous system depressants.

As of 2014, multiple drugs have been used for therapeutic intervention, including lidocaine, naloxone, thiamine, lorazepam, vecuronium, etomidate, propofol, tolazoline, yohimbine, atropine, orciprenaline, metoclopramide, ranitidine, metoprolol, enoxaparin, flucloxacillin, insulin.

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Xylazine spreads across the US: A growing component of the increasingly synthetic and polysubstance overdose crisis

https://www.sciencedirect.com/science/article/abs/pii/S037687162200117X