Thiazol

Fenbendazole

Methylene Blue

Melatonin

Thiamine (B1)

EDTA

Hydroxychloroquine Sulfate

Thiamine
Fenbendazole
Methylene Blue

Pyrimidine
Thiazole

Thiamine has a 6-Carbon & 5-carbon, smaller then a Benzene.

Thiamine deficiency leads to reduced nitric oxide production

Role of thiamine thiol form in nitric oxide metabolism

Thiamine pyrophosphate a regulator of the nitric oxide

https://www.eonutrition.co.uk/post/mega-dose-thiamine-beyond-addressing-deficiency

https://www.hormonesmatter.com/thiamine-deficiency-causes-intracellular-potassium-wasting/

https://en.m.wikipedia.org/wiki/Thiaminase

Serotonin Syndrome and Thiamine: Is There a Connection?

https://www.hormonesmatter.com/serotonin-syndrome-thiamine-connection/

Why Thiamine Supplementation Requires Magnesium; Thiamine Activation Requires Magnesium

https://www.hormonesmatter.com/why-thiamine-supplementation-requires-magnesium/

Thiamine Activation Requires Magnesium

https://www.hormonesmatter.com/why-thiamine-supplementation-requires-magnesium/

Mega-Dose Thiamine: Beyond Addressing “Deficiency”

https://www.eonutrition.co.uk/post/mega-dose-thiamine-beyond-addressing-deficiency

Thiamin and protein folding
Dr Lonsdale

https://www.sciencedirect.com/science/article/abs/pii/S0306987719300829?via%3Dihub

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Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation.

Thiamine plays an important role in helping the body convert carbohydrates and fat into energy.

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Prion = Resistant Starch

Thiamine = Carbohydrate Metabolism

Starch = Carbohydrate

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https://en.m.wikipedia.org/wiki/Thiazole

https://en.m.wikipedia.org/wiki/Epothilone

https://en.m.wikipedia.org/wiki/Sorangium_cellulosum

Commercial significant thiazoles include mainly dyes and fungicides. Thifluzamide, Tricyclazole, and Thiabendazole are marketed for control of various agricultural pests. Another widely used thiazole derivative is the non-steroidal anti-inflammatory drug Meloxicam.

The following anthroquinone dyes contain benzothiazole subunits:

Algol Yellow 8, Algol Yellow GC, Indanthren Rubine B, Indanthren Blue CLG, Indanthren Blue CLB.

These thiazole dye are used for dyeing cotton.

The principal mechanism of the epothilone class is the inhibition of the microtubule function. Microtubules are essential to cell division, and epothilones, therefore, stop cells from properly dividing.

Industrial fermentation and genetic manipulation of S. cellulosum is challenging.

Plasmids have been found to not function in S. cellulosum cells. Reproducible genetic alterations must be made directly into the single circular chromosome.

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Indole
Indolamine
Tryptophan
Tryptamine

Hydroxycitrate
Hypochlorous Acid (HOCl)

Thiamine
Glutathione
Potassium
Magnesium

Amide
Amine
Thiamine

Thia = Sulfur
Mine = Nitrogen

Transketolase
Alpha-Ketoglutarate Dehydrogenase
Pyruvate Dehydrogenase
Corneal Keratocyte

https://en.m.wikipedia.org/wiki/Indolamines

https://en.m.wikipedia.org/wiki/Tryptophan

https://en.m.wikipedia.org/wiki/Tryptamine

https://en.m.wikipedia.org/wiki/Indole

https://en.m.wikipedia.org/wiki/Aminoquinoline

https://en.m.wikipedia.org/wiki/Amide

https://en.m.wikipedia.org/wiki/Amine

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and B1 Thiamine does similar things as Methylene Blue.

B1 Thiamine was originally discovered & synthesized from a dye.

and it seems to help push out sodium from cells, and allow Potassium & Iron Hemoglobin back in.

i think the goal for B1 is to open up blocked mitochondria as an enzyme activator, allowing vitamins & minerals to be most effective, so taken with a good multivitamin is important.

Fenbendazole, Methylene Blue Melatonin.. all the most powerful compounds.. all look like Vitamin B1, or damn near close enough.

i took handfuls of B1 with Vitamin-C, E & Fish oil, specially to focus on my joint collagen.

i was fiddling around with Potassium, Sea Salt & Citric Acid, to get the ions sparked up, but something was missing, thats when i found out B1 puts Potassium inside the cell, where it is supposed to be for PH Buffer Homeostasis.

Potassium was one of the few elements that has direct neutralizing effects on Prion, the other was Brass.

DNA Parasite inside mitochondria, i think its metabolizing the iron, converting Heme into the toxic Oxide, and as a result displacing the Potassium.

making an environment to produce self assembling prion amyloidosis.

i dont want to fiddle too much with Copper & Zinc metals, because a pinch too much is overdose & death.

so it has to be the Potassium, thats how i discovered the chronic deficiency, deposits around infected cells, and how to put it backninto the cells, via B1 as an enzyme activator.

another thing, the literature says most B1 is water soluble & flushed out, requiring an ongoing high level treatments, but if taken with the other vitamins, i think its still doing things, even days after taking them, the Nitrogen & Sulfur is actually like Fenbendazole, meaning it has long lasting effects, possibly weeks of enzyme reactions.

also, Prion actually uses copper in its misfolding process.

[Structural Consequences of Copper Binding to the Prion Protein]

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found two papers comparing Amyloid with Protocell.

Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors

Steps Towards the Formation of A Protocell: The Possible Role of Short Peptides

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Glutathione is a tripeptide (cysteine, glycine, and glutamic acid) found in surprisingly high levels—5 millimolar—concentrations in most cells. This is the same concentration in cells as glucose, potassium, and cholesterol

Amides undergo many chemical reactions, although they are less reactive than esters. Amides hydrolyse in hot alkali as well as in strong acidic conditions. Acidic conditions yield the carboxylic acid and the ammonium ion while basic hydrolysis yield the carboxylate ion and ammonia.

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Resistant Starch
Retrogradation

https://en.m.wikipedia.org/wiki/Resistant_starch

glucose chains can reassociate into short crystalline structures, which typically involves rapid recrystallization of amylose molecules followed by a slow recrystallization of amylopectin molecules in a process called retrogradation.

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Metazoa
Bryozoa

Micrometazoa
Tardigrade

Evolutionary genomics in Metazoa: the mitochondrial DNA as a model system

https://www.sciencedirect.com/science/article/abs/pii/S037811199900270X?via%3Dihub

The rhizome of life: what about metazoa?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417402/

Thiamine (B1)
Pyrimidine
Thiazole

Thiophene
Thienyl
Thiazolyl
Thiazole
Thiamine

The structure of the infectious prion protein

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030906/

The prion protein binds thiamine

https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2011.08304.x

Oligomeric-Induced Activity by Thienyl Pyrimidine Compounds Traps Prion Infectivity

https://www.jneurosci.org/content/31/42/14882

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865802/

Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268695/

Chemical and genetic validation of thiamine utilization as an antimalarial drug target

https://www.nature.com/articles/ncomms3060

Syntheses of Thiophene and Thiazole-Based Building Blocks and Their Utilization in the Syntheses of A-D-A Type Organic Semiconducting Materials with Dithienosilolo Central Unit

https://pubs.acs.org/doi/10.1021/acsomega.2c02195

The importance of thiamine (vitamin B1) in humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568373/

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apparently only Nitrogen, Sulfur, Carbon, Oxygen & Hydrogen are capable og going 5-Carbon, small enough to wrech havoc on nano microbes.

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Self Assembling
Nanoplastics
Nanocrystal
liquid Crystal
Chitin Nanocrystals (CNCs)
Colloidal Particles
Superlattices

The structure and dynamics of chitin nanofibrils in an aqueous environment revealed by molecular dynamics simulations

https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra00107f

Microbial degradation of chitin (Enzymes, Steps, Mechanisms)

https://microbenotes.com/microbial-degradation-of-chitin/

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Mononegavirus
Filoviridae
Promoter (genetics)
Holoenzyme

Members that cause human disease in Mononegavirales order include Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus.

Mononegavirus RdRps bind to a single promoter located at the 3' end of the genome.

RNA polymerase holoenzyme shows high affinity to non-specific sites of the DNA, this characteristic does not allow us to clarify the process of promoter location.

Thiamine pyrophosphate and protein structure of transketolase.

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Thiamine deficiency (beriberi) is common in some parts of southeast Asia. Acute thiamine deficiency can mimic many complications of malaria, such as encephalopathy and lactic acidosis.