CBD for Glaucoma

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CBD for glaucoma has potent neuroprotective effects on patients with this condition. Early detection of glaucoma and the immediate start of treatment with CBD can definitely restrict the progression of the disease and prevent loss of vision.

According to the Glaucoma Research Foundation, glaucoma is the leading cause of irreversible blindness.

There are several extended studies done to evaluate the efficacy of different phytochemicals of cannabis. CBD is one of these active phytochemicals present in cannabis.

According to the National Eye Institute, in 2010, 2.7 million people in the U.S had glaucoma and by 2030 this will increase by 50% to 4 million (2050 - 6.3 million).

People between 40 years and 80 years of age have a higher tendency to develop glaucoma. Glaucoma is an irreversible condition and until now, medical science was unable to discover any curative treatment for it. However, early detection and immediate introduction of a neuroprotective regimen to constrain the optic nerve damage can restrict the progression of glaucoma.

What is Glaucoma?

Glaucoma is a complex eye disorder that eventually leads to blindness due to damage of the optic nerve. The optic nerve is the primary sensory nerve that helps in visualization. Common causes of glaucoma are:

• The death of optic nerve cells.
• The build-up of extreme fluid pressure within the eye, leading to optic nerve damage.
• Increase in Intra-ocular pressure (IOP / eye pressure) that obstructs blood circulation, lack of oxygen supply which then causes accumulation of excessive metabolic toxins within the eye.
• Family history of glaucoma due to defective genetic mutation can cause hereditary glaucoma.
• An immune response elevates IOP by attacking heat shock proteins, which is erroneously present in the optic nerve in the retina as foreign bodies.

Types of Glaucoma

Glaucoma can be classified as follows:

• Open-angle glaucoma: The angle between iris and cornea widens, which causes the eye drainage canals to become blocked. Fluid then gets accumulated inside the eye, causing high eye pressure. Almost 90% of glaucoma is open-angle glaucoma.
• Angle-closure glaucoma: This is the opposite condition of open-angle glaucoma. The angle between the iris and cornea narrows and blocks the eye drainage canals.
• Miscellaneous glaucoma: This includes normal-pressure glaucoma (optic nerve damage without elevated eye pressure) and congenital glaucoma (defective development of eye drainage canals at the prenatal stage). Apart from these, secondary glaucoma may also develop due to other co-morbid conditions, such as; eye inflammatory disease, diabetes, advanced cataract condition and side effects of certain drugs (including steroids).

Symptoms of glaucoma include:

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• No marked visual disturbance is observed at an initial stage
• Blind spot inside vision or central vision
• At the advanced stage, tunnel vision can develop

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Open-angle Glaucoma
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• Severe headaches
• Nausea & vomiting
• Red eyes
• Eye pain
• Blurred vision
• Radiance around lights

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Angle-closure Glaucoma
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Untreated symptoms of glaucoma can affect central eyes and can eventually lead to complete loss of vision.
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CBD for Preventing and Reversing Glaucoma

The conventional treatment for glaucoma aims to lower the intraocular pressure. The commonly prescribed treatments include medications, laser treatment and major surgery. For many patients, it becomes difficult to tolerate conventional medications due to the side effects.

Cannabidiol Properties for Glaucoma

Cannabinoids are the combination of different bioactive phytochemicals of cannabis. The following are just some properties which support CBD for glaucoma treatment:

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CBD significantly lowers eye pressure and has neuroprotective effects.
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CBD reduces neurotoxicity, inflammation, and blood-retinal barrier breakdown.
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CBD prevents retinal cell death and reduces vascular hyper-permeability.
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CBD acts as a p38 MAP kinase inhibitor and therefore significantly reduces eye pressure.
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CBD indirectly activates the CB₁ receptors and causes vaso-relaxation in arteries which reduces fluid pressure.
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CBD reduces high blood pressure.
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CBD modulates pain signaling and reduces the production of inflammatory mediators, therefore mitigating corneal pain symptoms.
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Laboratory Studies

In 1987, an animal research study was conducted on albino rabbits. According to the results, the systemic administration of cannabinoids lowers eye pressure through the alteration of blood pressure.

In 2006, a study conducted on diabetic rats reported that CBD treatment significantly inhibited p38 MAP kinase and reduced neurotoxicity, inflammation, and blood-retinal barrier breakdown.

A research paper published in 2016 reported that CBD activates the G protein-coupled receptor 18 (GPR18) to modulate the secretion of aqueous humor. In other words, it lowers eye pressure (IOP) and is therefore very effective for glaucoma treatment.

In 2018; Dinesh Thapa, Elizabeth A. Cairns et. al conducted animal research and reported that CBD has the ability to reduce corneal pain. The efficacy of anti-nociceptive and anti-inflammatory CBD effects was further confirmed by tests on mice.

The findings support the theory that topical application of CBD activates the 5-HT1A receptors and the cannabinoid 2 receptor, which reduce corneal pain by modulating pain signaling.

The same study report also demonstrated that other cannabinoids like Δ8THC and HU-308 also possess anti-nociceptive and anti-inflammatory effects. These contribute to the reduction of corneal pain by activating cannabinoid 1 and cannabinoid 2 receptors.

The efficacy of Δ9 THC and other active ingredients of cannabis was evaluated in another animal study. According to the findings, the topical administration of cannabinoids, including Δ9 THC has lowered intra-ocular pressure by 40%.

Clinical Studies

A trial conducted in 2004 on 33 people reported a decrease in eye pressure after jogging and confirmed that heart rate enhancement does not influence alteration of the intraocular pressure. In other words, an increase in heart rate due to CBD does not cause a clinical barrier in glaucoma treatment.

A small-scale clinical trial conducted in 2006 also reported that sublingual administration of Delta-9-THC and CBD provided a temporary lowering effect of the eye pressure.

A clinical trial conducted on 9 healthy male volunteers in 2017 reported that CBD was a well-tolerated substance. The author of this study concluded that CBD has a significant blood pressure lowering effect in association with increased heart rate.

A recent clinical trial report published in February 2018 demonstrated that topical application, in the form of eye drops, of a full spectrum cannabinoid extract has an anti-inflammatory effect, causing a reduction in eye pressure.

Anecdotal Evidence

There are numerous personal reports of people successfully treating their glaucoma with CBD. Take Steve and his mother-in-law from Tulsa, who both managed to normalize their eye pressure after using CBD oil for about a month and a half.

Diana from Pennsylvania reported that her eye pressure dropped from 40 to 16 (mm Hg) after using CBD for a month. She said her doctor couldn't believe it.

Al Morentin from California was steadily going blind after being diagnosed as a candidate for glaucoma in the sixth grade. When he started using cannabis oil, he stopped the decline in his eyesight and greatly relieved the pain and building pressure. However, when he ran out of the oil, he became blind in his right eye. Upon resuming the oil, his eyesight returned and he sees better today than he has in 10 years.
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Conventional Glaucoma Medication

The conventional medical system uses several ways to treat glaucoma; eye-drops, surgery and laser procedures are the most commonly used. However, there are side-effects or downsides to take into consideration as well.

Side Effects of Eye Drops:

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• Tolerance (the longer you use them, the less effective they become)
• Eye surface irritation
• Change in eye color
• Eye-lid skin darkens
• Eye discomfort

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• Eye redness
• Droopy eyelids
• Drowsiness
• Allergic reactions cause dryness of mouth and nose
• Fatigue

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Side Effects of Surgery:

• Temporary vision disruptions
• Increase the risk of eye infections
• Development of hypotony (low eye pressures) immediately after the surgical intervention
• In rare cases, bleeding can occur.

Downsides of Laser Procedures:

• The achieved reduction in eye pressure is typically not permanent and pressure will likely start creeping up again.

Due to these side-effects, an increasing number of glaucoma patients are looking for alternatives to treat this condition. [/av_textblock]

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CBD for Dogs with Glaucoma

Certain dog breeds are genetically prone to developing glaucoma, such as; poodles, siberians, chow chows and cocker spaniels. Despite medical or surgical intervention, 40% of dogs affected with glaucoma become blind.

Hemp oil (CBD) for dogs, however, works just like with humans which makes it a potentially great glaucoma treatment for dogs as well.
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CBD Dosage for Glaucoma

Marijuana smoke is known to treat glaucoma. In 2016, Dr. Gary D. Novack, Ph.D published his review report on the treatment of glaucoma with cannabinoids. This review confirmed that smoking marijuana decreased intraocular pressure by almost 30% in volunteers. However, due to the relatively short working span (peak at 2 hours), this regimen is not practical.

Sublingual Dosage

The sublingual dose of cannabinoid extract containing CBD oil is 20 mg to 40 mg in combination with 5mg Delta-9-THC. The duration of active working is approximately 4 hours. CBD oil should not be used more than 40 mg, as a higher dose can increase IOP.

Topical Application

CBD eye drops are well tolerated and probably provide the best result in terms of lowering eye pressure. Eye drops containing Δ9 THC can also provide a significant reduction of intraocular pressure. Eye drops typically provide relief for 8 - 12 hours.
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Please share your thoughts in the comment section below this article on what dosage worked best for your treatment. This way other people will benefit from your experience. Thanks!
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Success Stories From Glaucoma Patients

We have carefully collected CBD testimonials for this particular condition to serve as proof and inspiration to others. Do not hesitate to record your own experience and share it with us so we can add it to this list and help thousands of other patients.

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Overview of Scientific Studies and Reports

If you are interested in the medical proof and not scared of reading through some professional medical jargon, check out the studies below.
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• 1979 /5 - Effects of tetrahydrocannabinol on arterial and intraocular hypertension
• 1980/03 - Effect of marihuana on intraocular and blood pressure in glaucoma
• 1982/08 - Glaucoma, hypertension, and marijuana
• 1987/2 - Central nervous system and peripheral mechanisms in ocular hypotensive effect of cannabinoids
• 1998/11 - Marijuana smoking vs cannabinoids for glaucoma therapy
• 2000/00 - Marijuana as Medicine? The Science Beyond the Controversy
• 2003/11 - Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite
• 2004/3 - Correlating intraocular pressure, blood pressure, and heart rate changes after jogging
• 2004/05 - Cannabinoids and glaucoma
• 2006/01 - Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes
• 2006/10 - Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study
• 2016/03 - Cannabinoids for treatment of glaucoma
• 2017/06 - A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
• 2017/10 - Cannabinoids for Glaucoma
• 2018/ 02 - Evaluation of cannabinoid eye drops on five patients with intractable hypertensive open-angle glaucoma

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Best CBD for Glaucoma

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Sources:
https://www.fda.gov/newsevents/publichealthfocus/ucm484109.htm
https://www.glaucoma.org/research/optic-nerve-regeneration-1.php
https://nei.nih.gov/health/glaucoma/glaucoma_facts
https://www.mayoclinic.org/diseases-conditions/glaucoma/symptoms-causes/syc-20372839
https://www.glaucoma.org/news/what-causes-glaucoma-scientists-may-have-finally-figured-it-out.php
https://www.glaucoma.org/glaucoma/types-of-glaucoma.php
https://www.glaucoma.org/glaucoma/secondary-glaucoma.php
https://www.projectcbd.org/cbd-eye-drops-ocular-pain
https://www.leafly.com/news/health/cannabis-for-glaucoma-treatment
https://www.glaucoma.org/glaucoma/glaucoma-facts-and-stats.php
https://nei.nih.gov/eyedata/glaucoma
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