It is not definitively known how or when the Native Americans first settled the Americas and the present-day United States. The prevailing theory proposes that people migrated from Eurasia across Beringia, a land bridge that connected Siberia to present-day Alaska during the Ice Age, and then spread southward throughout the Americas over the subsequent generations. Genetic evidence suggests at least three waves of migrants arrived from Asia, with the first occurring at least 15 thousand years ago.
The pre-Columbian era incorporates all period subdivisions in the history and prehistory of the Americas before the appearance of significant European influences on the American continents, spanning the time of the original settlement in the Upper Paleolithic period to European colonization during the Early Modern period. While technically referring to the era before Christopher Columbus' voyages of 1492 to 1504, in practice the term usually includes the history of American indigenous cultures until they were conquered or significantly influenced by Europeans, even if this happened decades or even centuries after Columbus' initial landing.