In numerous mouse models2, prevention of EMT or its reversal — a process known as MET, in which mesenchymal cells transition back to epithelial cells
One model for how EMT might occur is that cells make a gradual transition from one state to the other along a continuous spectrum of change in which cells lose epithelial characteristics
This raises the question of whether these highly metastatic cells could be specifically targeted with drugs to arrest tumour progression. Interestingly, none of the stable subpopulations was superior to the others in terms of tumour-initiating capability or proliferation rate. Also, each of the subpopulations
