Introduction
In today’s world, pets have become beloved members of many families. But hidden dangers still threaten them — and us — silently. One of the most serious of these threats is Rabies, a viral disease that is almost always fatal once symptoms appear.
📌 What Is Rabies?
Rabies is an acute viral disease caused by the Rabies virus, a member of the Lyssavirus genus. It primarily targets the central nervous system (CNS) and is usually transmitted through the bite or saliva of an infected animal.
📉 Critical Fact: Once clinical signs appear in humans or animals, death is nearly inevitable.
🧠 Behavioral Changes: The First Red Flag
One of the earliest and most important signs of rabies is sudden behavioral change. The virus directly affects the brain by using a region in its glycoprotein that mimics snake venom, targeting nicotinic acetylcholine receptors (nAChRs) and disrupting neurotransmission.
📍 Common early behavioral symptoms:
Unprovoked aggression
Unusual fear or hiding
Excessive vocalization (barking or meowing)
Attacking objects or people without clear cause
📷 Scientific Illustration:
Figure: The rabies virus alters host behavior by using a snake-toxin-like motif in its glycoprotein to inhibit nicotinic acetylcholine receptors (nAChRs) in the brain. This neuroinhibitory mechanism leads to aggression, disorientation, and paralysis in infected animals. Source: Hueffer et al., Scientific Reports, 2017 https://doi.org/10.1038/s41598-017-12726-4
🔍 Other Advanced Signs in Animals:
Excessive drooling or foaming at the mouth
Inability to swallow (hydrophobia)
Tremors or seizures
Paralysis of limbs
Death within days of symptom onset
🛡️ How to Protect Your Pet and Yourself:
💉 Keep your pet’s vaccinations up-to-date, especially for dogs and cats
🚫 Prevent contact with stray or wild animals
👨⚕️ Schedule regular veterinary checkups
🔍 Watch closely for any unusual behavior in your pet
✅ Final Thoughts
If you're a pet owner, early detection of abnormal behavior can save lives — yours and your pet's. Rabies may seem rare in modern life, but in many parts of the world (including Iran), it’s still a real and present danger.
Stay alert. Stay informed. Knowledge is the best vaccine.
💬 Your Thoughts: Have you ever encountered a rabid animal or seen suspicious signs in a pet? Share your experiences or questions in the comments — I’d love to hear from you.
✍️ Written by: Dr. Masoud Doosti (DVM, DVSc) Veterinarian | Science Writer | Pet Health Advocate
