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Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion

Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion

CD8+ T cell exhaustion impedes control of chronic viral infection and cancer. This hypofunctional state is characterized by downregulation of the high-affinity IL-2 receptor (IL-2R) and STAT5 signalling,

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