Digital artwork created entirely in Zbrush in 2010.
It is pixol based,at unique technique that can mix 2d and 3d together.
(From Zbrush docs).In 2D images the basic building block is a pixel (from ‘picture element’). Pixels contain information about their position on the 2D plane (their X and Y co-ordinates) and color (their Red, Green and Blue values). ZBrush takes this a step further by adding depth, orientation and material, making a smart pixel which is called a pixol.
This technique is similar in concept to a voxel, another kind of 3D pixel.
Here are some details.