Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data

By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Influenza. According to news reporting from Oxford, United Kingdom, by NewsRx journalists, research stated, “Primary care clinicians have a central role in managing influenza/influenza-like illness (ILI) during influenza pandemics. This study identifies risk factors for influenza-related complications in children presenting with influenza/ILI in primary care.”

The news correspondents obtained a quote from the research from the University of Oxford, “We conducted a cohort study using routinely collected linked data from the Clinical Practice Research Datalink on children aged 17 years and younger who presented with influenza/ILI during the 2009/10 pandemic. We calculated odds ratios (ORs) for potential risk factors in relation to influenza-related complications, complications requiring intervention, pneumonia, all-cause hospitalisation and hospitalisation due to influenza-related complications within 30 days of presentation. Analyses were adjusted for potential confounders including age, vaccination and socio-economic deprivation. Asthma was a risk factor for influenza-related complications (adjusted OR 1.48, 95% confidence interval (CI) 1.21-1.80, p<0.001), complications requiring intervention (adjusted OR 1.44, 95% CI 1.11-1.88; p=0.007), pneumonia (adjusted OR 1.64, 95% CI 1.07-2.51, p=0.024) and hospitalisation due to influenza-related complications (adjusted OR 2.46, 95% CI 1.09-5.56, p=0.031). Neurological conditions were risk factors for all-cause hospitalisation (adjusted OR 4.25, 95% CI 1.50-12.07, p=0.007) but not influenza-related complications (adjusted OR 1.46, 95% CI 0.83-2.56, p=0.189).”

According to the news reporters, the research concluded: “Community-based early interventions to prevent influenza-related clinical deterioration should therefore be primarily targeted at children with asthma and neurological conditions.”

For more information on this research see: Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data. Epidemiology and Infection , 2018;():1-7. Epidemiology and Infection can be contacted at: Cambridge University Press, 32 Avenue of the Americas, New York, NY 10013-2473. (Cambridge University Press - www.cambridge.org; Epidemiology and Infection - http://journals.cambridge.org/action/displayJournal?jid=HYG)

Our news journalists report that additional information may be obtained by contacting J.J. Lee, Nuffield Dept. of Primary Care Health Sciences, University of Oxford, Oxford, UK. Additional authors for this research include C. Bankhead, M. Smith, A.A. Kousoulis, C.C. Butler and K. Wang.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1017/S0950268818000353. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Epidemiology and Infection is: Cambridge University Press, 32 Avenue of the Americas, New York, NY 10013-2473.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC

CITATION: (2018-04-30), Studies from University of Oxford in the Area of Influenza Reported (Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data), Clinical Trials Week, 1190, ISSN: 1543-6764, BUTTER® ID: 015597091

From the newsletter Clinical Trials Week.
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