OVERVIEW • Sickle cell anaemia occurs commonly in individuals from African, Middle Eastern and Indian populations • Neonatal screening of appropriate populations can result in a signifi cant decrease in

OVERVIEW • Macrocytic red cells (MCV greater than 95fl ) may be associated with a megaloblastic or normoblastic bone marrow • Deficiencies of either vitamin B12 or folate lead to defective DNA synthesis,

Overview • Iron defi ciency is the commonest cause of anaemia worldwide • Iron defi ciency is usually easily diagnosed from the red cell indices • A drop in haemoglobin is generally a late feature of iron