One thing that I think is going to be huge for RUNE (although I don't know when/if it's on the roadmap at this point) is a privacy coin pairing. Privacy coins are awesome, but the problem is that you always need to use a centralized exchange to trade them. If THORchain implements Monero, for example, then you could trade BTC for XMR and then trade your XMR back into BTC into a new wallet address without providing any KYC info and you would have clean BTC that no one can trace, which I think will be a game changer for privacy.
RE: Rune Chameleon