I had no idea the Smurfs dated back to the '60s. Yeah, I was a kid growing up in the '60s, but never heard of them back then. This is a good bit of television history.

As for other cartoons that have been around for ages -
Scooby-Doo (I mentioned that on discord - would enjoy seeing how you tackle that one)
Johnny Quest also comes to mind with its iconic jazz theme song.

Both of these series have had comic book series over the years

Maybe Duck Tales? I haven't seen many of the episodes, but what I have seen has been good