The first 20 minutes did not see any serious chance for both teams, but Liverpool received an early blow, after the injury of Brazilian player Fabinho injury, and entered the place of the Dutch Jorginho Vinaldom.
Dries Mertens scored the lead for Napoli in the 21st minute, while Diane Lovren scored the equalizer for Liverpool (65).
Liverpool stayed top of Group E with a 1-1 draw at home to Napoli on Wednesday evening at Anfield in the fifth round of the Champions League group stage.
The draw brings Liverpool to 10 points in the group, one point behind Napoli, but their progress to the final was postponed for the final round, after Red Bull Salzburg (7 points) beat Genk 4-1.
Mohamed Salah returned to the Liverpool squad after recovering from injury.He played in the attacking triangle alongside Roberto Firmino and Sadio Mane, but German coach Juergen Klopp rested the brilliant right-back Trent Alexander-Arnold and brought in Joe Gomez.
On the other hand, the absence of Napoli injured injury winger Italian Lorenzo Insigne, and returned to the lineup of Fabian Ruiz and Costas Manolas, after missing the last team meeting against Napoli.