The quality of your skin is primarily determined by epigenetics, a biological mechanism that inherently controls your skin's age, healthiness, and beauty state, and makes skin dynamic and reversible. The proprietary EpigenCare(TM) skincare test is a scientifically grounded assay to accurately detect the epigenetic states of your skin. This allows for true optimization of skincare products for you based on the unique epigenetic profile of your skin as well as the active ingredients of popular skincare products that could epigenetically impact you.
Using the latest technology, EpigenCare deploys next-generation sequencing, the gold standard to validate unique epigenetic characteristics.
Your skin's epigenetic states are critical determinants of your skin's health and beauty, which can be reliably identified through our scientifically-backed EpigenCare™ test analysis:
AGING
Age dependent epigenetic changes, specifically DNA methylation signatures, have become a hallmark of aging. Skin aging shows dryness, loss of firmness, decrease in elasticity, and an increased risk of wrinkles, acne, and cancer.
FIRMNESS & ELASTICITY
Collagen and elastin proteins hold your skin together and maintain elasticity. Decrease of these proteins causes fine wrinkles, elasticity loss, reduced thickness, and looseness. The major enzymes or proteins that are responsible for formation, metabolism, secretion, and glycation of collagen and elastin are epigenetically controlled and regulated through DNA methylation or histone modification.
MOISTURE
Moisture is maintained by water transportation proteins and is essential for smooth and bright skin. It also helps with the elasticity of the stratum corneum, preventing tightness and cracking. Activation or repression of water transportation proteins is critically dependent on epigenetic regulation.
DNA DAMAGE & REPAIR
Environmentally-induced DNA damage is mainly due to excessive exposure to UV radiation in the form of sunlight as well as cigarette smoke and other pollutants. Epigenetic activation of DNA-repair genes or repression of DNA damage reaction pathways become vital for controlling DNA damage/repair mechanisms and cell regeneration.
CELL REGENERATION
Skin cell renewal/regeneration refers to the regrowth of lost skin cells in response to damage or cell death. Weakened ability of cell renewal/regeneration will cause aged skin with wrinkles, age spots, and dryness. The skin also becomes thinner and loses fat, making it appear less full and smooth. Epigenetic changes are proven to be critical determinants for control and regulation of cell renewal and regeneration.
SENSITIVITY RESPONSE
Sensitive skin and inflammatory response from an immunity reaction to environmental stimuli such as irritants or pollutants can lead to itchiness, redness, peeling, etc., often due to inflammatory protein actions such as cytokines. Regulatory genes or proteins/enzymes for sensitive and inflammatory response pathways are controlled by DNA and histone modification-related gene activation or inactivation.
OXIDATION & ANTIOXIDATION
Oxidative damage results from an imbalance between free radical generation and antioxidant defenses, which unfavorable symptoms including age spots, wrinkling, and sagging. It is well known that oxidation and antioxidation pathways are controlled by epigenetics, especially by DNA methylation/demethylation of the genes regulating these pathways.
PIGMENTATION
Coloration of the skin is dependent on the amount of melanin present in the skin, with over-pigmentation from sun exposure or aging leading to skin disease. Skin pigmentation is closely related to epigenetic activation or inactivation of regulatory genes of pigmentation.
