Other machines made by Capcom during the time period Buster Bros. was produced include U.N. Squadron, Capcom Baseball, Area 88, Dynasty Wars, Willow, LED Storm, Daimakaimura, Ghouls 'n Ghosts, Last Duel, and Capcom Bowling.
One or two players cooperatively destroy bouncing balls with a variety of weapons. The players may only fire up, but may move right and left, or up and down ladders. The large balls that have been shot split in two, creating smaller balls.