it works fine for me i even have my witnesses running in proxmox without any problems , and i also use it on my UGREEN dxp 8800 plus NAS , where i run truenas in proxmox and when needed i can also run other things on there in the future :) like a gameserver .

you can dedicate the sata controller to a VM in my case i dedicated one of the sata controllers to my truenas vm

and my other proxmox server is running the pfsense router + 2 hive witnesses