This depends on your play style more than anything. There are so many variables there is no one splinter or elite set cards within it that can be called the best.

However, using cards you're familiar with, and know how to pair with one or two others to exploit a given ruleset is about as good as you can get in regard to optimal odds.

I may be wrong, but I think building a solid little league team, using as many neutrals, to fill as many specialized positions as you can, puts you in a position to always have access to a small team of personal elites you can scatter anywhere.