How do you react to differences in religion, race, culture, politics, economy, and social?
It really depends. Personally I have no problem with someone else's any one of those things as long as they aren't in my face about it.
But tell me that I'm going to a bad place because I don't follow your religion? Tell me that my being white is inherently bad despite the fact I am aware of my white privilege and try to use it to help where I can? Have a cultural, political or social view that literally threatens the lives and rights of other human beings for reasons of race, religion, gender and sexual identity, ect? Yeah, we're going to have a problem and I will tear you apart. I'm studied enough in those areas to shut down anyone who tries to tell me otherwise because I got sick of being told stuff like that and decided educating myself to counter argue was the best way to go about things.