Thanks! The main problem a lot of research faces is framing.
We already intuitively view cancers as self-organising dynamical systems due to the somatic evolutionary nature of the disease, and this allows us to intuitively fit research into developing our understanding, but we often fail to translate this self-organising dynamical system framing into treatments, aiming just to target one area at one time, and then wondering why the treatment failed as the dynamical system alters itself to maintain disease status.

Framing is a powerful psychotechnology, and hopefully it will be adopted across all complex "I don't know" diseases, such as Arthritis as one example of a disease that could benefit from the framing as a self-organising dynamical system.