The constant risk of irreversible, permanent loss – If hackers steal private keys by breaching into client´s cryptocurrency exchange account, then it is possible to lose all money as cryptocurrency transactions are irreversible because of Blockchain and this loss will be permanent.
Security incidents at cryptocurrency exchanges or wallets are common as only in 2017 it is estimated that more than $150 million has been stolen or lost. While scams and phishing also happen with stocks, stocks and deposits cannot just disappear permanently. Even if hackers somehow succeeded in wiring customer´s money to themselves, these wires can be reversed.