Jon's Jacob berzelius by trade, first coined the term "organic chemistry" in 1806 for the study of compounds derived from biological sources. Up through the early 19th century, naturalists and scientists observed critical differences between compounds that were derived from living things and those that were not.

Chemists of the period noted that there seemed to be an essential yet inexplicable difference between the properties of the two different types of compounds. The vital force theory, sometimes called "vitalism" (vital means "life force"), was therefore proposed, and widely accepted, as a way to explain these differences, that a "vital force" existed within organic material but did not exist in any inorganic materials.