Both characters are terrible! Many people will disagree, but Sakura is a flat character. She is poorly constructed and has little relevance to the story.

In Misaka's case, it's chaotic. Although she has thousands of emotions for me, she is one of the least impactful characters in the anime industry. Mainly, her personality sucks.

The end of the story is a kind of romantic quest in a world full of monsters that eat humans. The concept is gore, not romance, let alone drama.

Both characters have a role in the manga. They are meant to be important, but they are not the center of everything. Personally, I like Sakura better (I never thought I'd say that, xd). However, I consider Bulma, Kagome, Nami, Rukia, Nico Robin, and Miss Wednesday to be the best female characters.

In Naruto, the one who stands out the most is Tsunade Senju, xd.