Re:Zero is the best Isekai anime in history, without exception. Of the three you mentioned, it has an impeccable mix and development. From its protagonist to its animation that remains consistent throughout all its seasons, Re:Zero manages to overcome any problem that all other generic Isekai anime possess. A unique story, a REAL protagonist, a fantastic and dark world, WELL-developed characters, and excellent construction between story, plot twists, unforgettable antagonists, and more.

Those that come close to its magnificence are: 1) Mushoku Tensei for its great story and characters and 2) Tensei Shitara Slime Datta Ken (if I'm not mistaken, that's how it's spelled) for its story,characters, world-building, and power hierarchies.

Ah! And KonoSuba is GOD!