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Diabetic neuropathy is a kind of nerve damage that can occur due to diabetes. It is a serious and common complication of type 1 and 2 diabetics. It is caused by long-term high blood sugar levels (glucose), which can injure the nerves throughout the body. Several medications can help relieve the pain associated with diabetic neuropathy, including over-the-counter pain relievers, prescription medications, and topical medications.