ascorbate can wipe a cell developmental memory epigenetic memory erasure TET family of DNA hydroxylases vitamin C adult somatic cells unlocks and clears epigenetic methylation tags on DNA erases cellular memory of an adult cell reverting it back into unprogrammed pluripotent stem cell TET demethylation myelin sheath

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

https://pubmed.ncbi.nlm.nih.gov/27729528/

Ascorbate (vitamin C) acts as a powerful epigenetic regulator that directly boosts the erasure of cellular memory. It achieves this by functioning as a vital cofactor that enhances the catalytic activity of the TET (Ten-Eleven Translocation) family of DNA hydroxylases. This cellular mechanism is a cornerstone of regenerative medicine. It allows scientists to unlock and clear restrictive epigenetic methylation tags on DNA, effectively helping to revert mature somatic cells into an unprogrammed pluripotent stem cell state.

Vitamin A and C Myelin Sheath Schwann Cell Myelination Demethylation DNA