Sulfur Cycling Balance: The unabsorbed sulfate (SO42) acts as a metabolic substrate for local microbes. While it supports necessary microbial sulfur cycling, the concurrent presence of magnesium keeps toxic hydrogen sulfide (H2S)-producing bacteria from overgrowing.

Nucleic Acid & Methylation Support: Magnesium acts as a core structural stabilizer for DNA and RNA, protecting the rapid nucleic acid synthesis and epigenetic modifications driven by the one-carbon cycle.

Enzymatic Driving Force: Key enzymes that transfer methyl groups throughout the methionine cycle rely completely on magnesium-dependent ATP reactions.

Fueling Transsulfuration: The sulfate portion of MgSO4 directly feeds into the transsulfuration pathway. This preserves the body's internal sulfur pool, freeing up one-carbon resources to synthesize S-adenosylmethionine (SAMe) (the body's master methyl donor) and glutathione (the body's master antioxidant).

The Microbiome Link: A healthy gut microbiome actively synthesizes B-vitamins (folate and B12). By optimizing gut bacteria, magnesium sulfate indirectly increases the primary raw inputs required to keep the folate and methionine cycles turning efficiently.

The ATP Lock: Free Mg²⁺ binds directly to Adenosine Triphosphate (ATP) to form Mg-ATP. ATP cannot be used by the cell unless it is bound to a magnesium ion.

Glycolysis: Glucose and honey (fructose/glucose) enter glycolysis. This pathway requires Mg²⁺ as a mandatory cofactor for rate-limiting enzymes like hexokinase and phosphofructokinase.