PI3K/AKT/mTOR
PI3K-mTOR Decoupling
SIN3-HDAC Inhibition
α-ketoglutarate (a-KG)
Chromatin Remodeling
Transcriptional Derepression
Histone Deacetylase HDAC
Chloride Channel Activation

PI3K/mTOR INHIBITION MARKEDLY POTENTIATES HDAC INHIBITOR ACTIVITY IN NHL CELLS THROUGH BIM- and MCL-1-DEPENDENT MECHANISMS

https://pmc.ncbi.nlm.nih.gov/articles/PMC4166554/

https://www.airmidbiogenetics.com/gene-reprogramming-paper

Ascorbate also directly modulates the PI3K/AKT/mTOR signaling pathway