Mycoplasma fermentans and magnesium (Mg2+) are interconnected in several ways, primarily concerning the bacteria's survival, adherence to host cells, and potentially its pathogenic effects.

Studies have shown that Mycoplasma fermentans adherence to HeLa cells is dependent on divalent cations like Mg2+.

Magnesium plays a critical role in maintaining bacterial membrane integrity and stability.A study involving Vibrio alginolyticus demonstrated that high magnesium levels modulate phospholipid metabolism, potentially increasing membrane polarization and decreasing permeability, leading to increased antibiotic resistance.

Research involving Mycoplasma fermentans strain K10 demonstrated that when membranes are dissolved in detergents and reaggregated by dialysis in the presence of Mg2+, the resulting lipid-protein complex becomes toxic.