Prion Disease is Caused by an Imbalance of the Magnesium/Manganese Ratio, A Hypothesis
Magnesium/Manganese Imbalance: One hypothesis proposes that an imbalance in the manganese-to-magnesium ratio, rather than solely magnesium deficiency, may contribute to the pathology of prion disease, particularly chronic wasting disease (CWD). This suggests the interplay between these two metal ions may be significant in prion pathogenesis.
Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue.
https://en.m.wikipedia.org/wiki/Manganism
The exact neurotoxic mechanism of manganese is uncertain but there are clues pointing at the interaction of manganese with iron, zinc, aluminum, and copper. Based on a number of studies, disturbed iron metabolism could underlie the neurotoxic action of manganese.
Manganese displaces Iron in the COQ7 hydroxylase enzyme required for coenzyme Q10 synthesis.
Mn's essential role and toxicity: Manganese is an essential micronutrient for the brain's normal development and function. However, both insufficient and excessive levels of Mn can lead to neurological dysfunction.
Excess manganese exposure can result in manganism, a permanent neurological disorder with Parkinson's-like symptoms. Manganism involves the accumulation of Mn in the basal ganglia, particularly the globus pallidus.
Research indicates that the binding of calcium enhances the interaction between the fusion peptide of the spike protein and the host cell membrane.
Calcium and magnesium ions interact with the spike protein and influence its function and the overall infection process.
One hypothesis suggests that magnesium ions, acting as natural antagonists to calcium in many cellular processes, might inhibit SARS-CoV-2 infection.
While calcium seems to be involved in facilitating the spike protein's function and viral entry, magnesium may have potential antiviral properties and could be a useful therapeutic target.
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How pathogens feel and overcome magnesium limitation when in host tissues
https://pmc.ncbi.nlm.nih.gov/articles/PMC7855738/
Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine
https://pmc.ncbi.nlm.nih.gov/articles/PMC9978992/
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Benzimidazole
Fenbendazole
Mebendazole
Albendazole
Omeprazole Magnesium
Losec, Prilosec, Zegerid, Miracid, Omez
Benzimidazole
Vitamin B12: Benzimidazole is an integral part of vitamin B12, a crucial coenzyme involved in various metabolic pathways, specifically N-ribosyl-dimethylbenzimidazole, is an integral part of this vitamin, which is essential for various bodily functions.
New Discovery of Unique 13-(Benzimidazolylmethyl)berberines as Promising Broad-Spectrum Antibacterial Agents
Benzimidazole
Benzene C6
Imidazole C5
Methylcobalamin B12
Thiamine (Thiamin) B1
Thiamine and thiamin are two spellings of the same word, which refers to vitamin B1.
Magnesium is involved in enzymatic processes that convert inactive forms of B12, such as cyanocobalamin, into the active forms like methylcobalamin.
A deficiency in magnesium could impact B12's effectiveness within the body.
Methylcobalamin and cobalt are inextricably linked as the active form of vitamin B12 and its central metal ion, respectively. Magnesium, while not directly interacting with them, plays a supportive role in B12 metabolism.
Cobalt-containing ring-contracted modified tetrapyrrole represents one of the most complex small molecules made by nature.
While essential in minute quantities within B12, excess cobalt can be toxic to cells, competing with other metal ions like magnesium and zinc for binding sites in proteins, and potentially causing oxidative stress and DNA damage.
Since cobalt is an integral part of vitamin B12, a deficiency in cobalt is equivalent to a vitamin B12 deficiency, leading to conditions like pernicious anemia, characterized by fatigue, weakness, numbness and tingling in extremities.
Neuroprotective Supplements:
Certain vitamins and minerals, such as vitamin C, vitamin E, and magnesium, may offer protection against excitotoxicity by acting as antioxidants and potentially reducing glutamate levels, protecting against excitotoxicity by reducing calcium influx into neurons and influencing cell survival pathways.
Some antibiotics, such as aminoglycosides like gentamicin and tobramycin, can lead to magnesium loss through urine.
Taking magnesium supplements too close to these antibiotics can reduce their effectiveness.
ATP Production: Mg²⁺ is necessary for the activity of ATP synthase, the enzyme that produces ATP, the main energy currency of cells, during oxidative phosphorylation, a process linked to the citric acid cycle.Energy Metabolism Regulation: Mitochondrial Mg²⁺ concentration can regulate the rate of energy production in response to energy demands. The decrease of mitochondrial Mg²⁺ concentration has been shown to affect the metabolome, particularly reactions in the TCA cycle.
Energy Metabolism Regulation: Mitochondrial Mg²⁺ concentration can regulate the rate of energy production in response to energy demands. The decrease of mitochondrial Mg²⁺ concentration has been shown to affect the metabolome, particularly reactions in the TCA cycle.
Through a series of reactions, citrate is oxidized, releasing energy in the form of NADH and FADH2, which are then used in the electron transport chain to produce ATP (cellular energy).
Citrate is also shuttled out of the mitochondria into the cytoplasm where it can be used for the synthesis of fatty acids, lipids, and cholesterol.
Citrate ions can also act as a stabilizing agent (or capping agent) by adsorbing onto the surface of nanoparticles, preventing aggregation.
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Cobalt deficiency is essentially a B12 deficiency, and Magnesium & Cobalt compete for the same Protein ion bonds.
what it appears to me, Fenbendazole & Thiamine sharing the same chemical component, is directly linked to B-12, meaning it will bind to both Cobalt & Magnesium, essentiality chelating it out into depletion.
the symptoms of Fenbendazole Toxicity is identical to B12 & Magnesium deficiency.
the most powerful anticancer & anti worm medicines are nearly identical to B1 & B12, and how Cobalt & Magnesium are so similar to be almost interchangeable, and both can be stripped out together.
what i dont know yet for sure, does Magnesium somehow protect B12 via Cobalt stabilizing, meaning its may not be necessary to supliment high dose B12, because Cobalt has a considerably stronger bond?
antibiotics seem to also disrupt Magnesium.
Magnesium appears to require something like a Simple Sugar, an Acid, plus a Nitrogen & Sulfur to chelate into metabolism TCA Citric Acid Krebs Cycle, otherwise its mostly 90% excreted.
thats the same extra ingredients as a dewormer & antibiotic, spike the Magnesium.
Vitamin C with the Magnesium, for whatever reason it appears all metabolic blocks seem to circle around the enzyme humans cant make for Vitamin C.
im loaded upnon Magnesium, Potassium & Sea Salts, feeling pretty good, then decided something is still missing.
loaded up on C, first thing noticed in day three is all my muscles are pumped up, buffed out.
apparently Vitamin C is the metabolic lock for Magnesium to do the thing.
our bodies are like a sewing machine factories, our cells make threads that become encoded with DNA beads.
what i noticed taking the Sea Salts with normal Chloride that salt has, the Vitamin C opened up the salts, i can smell like after swimming in a Chloride swimming pool, my muscles pumped up & loose joints seemed to lock into socket.
its like it pulled all the loose strings together.
1000 enzyme reactions between Magnesium & Niacin, my concern is they dont necessarily feel like those kind of reactions are actually happening without Vitamin C.
Vitamin C is only said to have like 10 enzyme reactions, but seems like they are very important ones.
my suspension is C not being made in human biosynthesis, makes me think its a bigger part of the enzyme flipping then we understand.
C is sensitive to air, water & heat degeneration, difficult to harvest naturally, and the synthetic ascorbic acid is also prone to the same degeneration.
making it a difficult vitamin to be absolutely dependent upon, so i just kind of ignored it.
the best source of Vitamin C in nature appears to be Citrus Peel, also a source of Mannose.
its a Simple Sugar with an unusual hydrogen/proton, acid/base configuration.
to make synthetic requires a chemical factory, its far too dangerous to make in the kitchen.
if in an environment without an abundance of Citrus fruit peels, or Pine nettles, im not sure.
Vitamin C seems to bind to Sugars, making the sweet part of fruits not very bioavailable.
just seems strange humans are required to have Vitamin C, and it being so difficult to supliment naturally.
and how pesticides destroy C & Magnesium.
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Co2+ Selectivity of Thermotoga maritima CorA and Its Inability to Regulate Mg2+ Homeostasis Present a New Class of CorA Proteins
https://pmc.ncbi.nlm.nih.gov/articles/PMC3091257/
Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress
https://www.nature.com/articles/srep30027
Selective molecular transport across the protein shells of bacterial microcompartments.
RE: Intercellular Homeostasis