Magnesium ions mediate ligand binding and conformational transition of the SAM/SAH riboswitch

https://www.nature.com/articles/s42003-023-05175-5

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SAM/SAH Riboswitch deactivation is likely responsible for the Homocysteine problems, where the metabolism gets locked up with a cascade of Inflammation.

Magnesium facilitates the release and function of GABA in the brain. It acts as a cofactor for enzymes involved in GABA synthesis, ensuring that our calming neurotransmitter is produced in adequate amounts.