Hydrogen Bonds in Proteins: Role and Strength

https://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0003011.pub2

In Protein Structure:

Hydrogen bonds contribute to the folding and stability of protein secondary structures like alpha helices and beta sheets.

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Epinephrine

In Anaphylaxis: In individuals with a severe bee sting allergy (anaphylaxis), the venom triggers a strong immune response, leading to the release of various mediators, including histamine. Histamine, in turn, can activate NO production. This increased NO level can contribute to symptoms like hypotension and bronchospasm (tightening of airways).

Methylene Blue Treatment: Methylene blue is a drug that inhibits the effects of NO by acting as a guanylyl cyclase inhibitor. It has been explored as a potential treatment for anaphylactic hypotension that doesn't respond to other interventions.