Redox
Chelation
Enzyme
Metabolism
Detoxify
OCM
One-Carbon Metabolism
Coenzyme-A
Nitrogen
Redox
Enzyme
Folate
Serine
Folate Cycle
Methionine Cycle
Regulatory mechanisms of one-carbon metabolism enzymes
https://www.sciencedirect.com/science/article/pii/S0021925823024857
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Folate
C19H19N7O6
NAC
C5H9NO3S
Niacin
C6H5NO2
Niacinamide
C6H6N2O
Inositol Niacinate
C42H30N6O12
Nicotinate
C6H4NO2
Inositol
C6H12O6
Dimethyl Sulfone
C2H6O2S
..
Melanins (good)
C18H10N2O4
Melatonin (good)
C13H16N2O2
Tryptophan
C11H12N2O2
Serotonin
C10H12N2O
Indoxyl Sulfate (Indican)
C8H7NO4S
Indoxyl Glucuronide
C14H15NO7
Indoxyl-Beta-D-Glucoside
C14H17NO6
..
A Mathematical Model of the Folate Cycle
NEW INSIGHTS INTO FOLATE HOMEOSTASIS
https://www.jbc.org/article/S0021-9258(18)66253-2/fulltext
5-methyltetrahydrofolate (the “methyl trap”), high homocysteine concentrations.
Toxic Medications
Methotrexate
https://en.m.wikipedia.org/wiki/Methotrexate
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Overmethylation and Undermethylation: Case Study
https://mthfr.net/overmethylation-and-undermethylation-case-study/2012/06/27/
Methyl-Free vs. Methylated: Do you Need a Non-Methylated Supplement?
Creatine and Creatinine Metabolism
https://journals.physiology.org/doi/full/10.1152/physrev.2000.80.3.1107
Creatine
Creatinine
Indoxyl Sulfate
How the use of creatine supplements can elevate serum creatinine in the absence of underlying kidney pathology
https://pmc.ncbi.nlm.nih.gov/articles/PMC4170516/
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Methyl Doner
Methylation
Methylfolate
Methylcobalamin
The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases
https://pmc.ncbi.nlm.nih.gov/articles/PMC7554709/
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Uremic Toxins
Uremic Salts
Indoxyl Sulfate
https://en.m.wikipedia.org/wiki/Indoxyl_sulfate
Redefining Roles: A Paradigm Shift in Tryptophan–Kynurenine Metabolism for Innovative Clinical Applications
https://www.mdpi.com/1422-0067/25/23/12767
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Stem Cell Regeneration
Aloe Macroclada
Blue Green Algae
Kidney
..
Stem Cell
Coenzyme-A
Histone Crotonylation
N-acetylcysteine regulates dental follicle stem cell osteogenesis and alveolar bone repair via ROS scavenging
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03161-y
Vitamin C and B3 as New Biomaterials to Alter Intestinal Stem Cells
https://pmc.ncbi.nlm.nih.gov/articles/PMC6626554/
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Stem Cells
Telomere
Telomerase
Telosome
Shelterin
MSC
Mesenchymal Stem Cells
HGH
Human Growth Hormone
The contribution of growth hormone to mammary neoplasia
https://pmc.ncbi.nlm.nih.gov/articles/PMC2665193/
Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications
https://pmc.ncbi.nlm.nih.gov/articles/PMC6412771/
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy
https://www.sciencedirect.com/science/article/pii/S155041312030190X
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CH3
Methyl Doner
Single/One-Carbon
Osmolyte
..
NAM
Methylation
Nicotinamide
Methylnicotinamide
MNA
2PY 4PY
Pyridone
Indoxyl Sulfate
Inositol
Hexanicotinate Niacinate
The Biochemical Pathways of Nicotinamide-Derived Pyridones
https://pmc.ncbi.nlm.nih.gov/articles/PMC7866226/
The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease
https://www.sciencedirect.com/science/article/abs/pii/S0168365922008732
Delivery of nitric oxide with a pH-responsive nanocarrier for the treatment of renal fibrosis
https://www.nature.com/articles/s41598-022-10476-6
Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme
https://pmc.ncbi.nlm.nih.gov/articles/PMC5446048/
An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite
https://www.nature.com/articles/s12276-021-00669-w
Synthesis, Detection, and Metabolism of Pyridone Ribosides, Products of NAD Overoxidation
https://pubs.acs.org/doi/10.1021/acs.chemrestox.3c00264
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GPR109A
Niacin Receptor 1 (NIACR1)
Hydroxycarboxylic Acid Receptor 2
https://en.m.wikipedia.org/wiki/Hydroxycarboxylic_acid_receptor_2
Butyric Acid
https://en.m.wikipedia.org/wiki/Butyric_acid
Trigonelline
Methylated Niacin
https://en.m.wikipedia.org/wiki/Trigonelline
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Niacin
Nicotinic
NAD
ATP
pH Alkaline 7
Enzyme Reactions
Cell Life Versus Cell Longevity: The Mysteries Surrounding the NAD+ Precursor Nicotinamide
https://pmc.ncbi.nlm.nih.gov/articles/PMC2248696/
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Nitrogen into Nitric Oxide requires a Ph 7 to activate enzymes.
Nician triggering enzyme reactions at more alkaline ph 7, makes mitochondria ATP & NAD, breaks up toxic acid buildup.
Inositol Niacin buffered with a Methyl Carbon & pinch of Electrolyte Citrate-Buffered Minerals & Bicarbonate.
DMSO/MSM helps with the coenzyme & metabolism, but needs much less then Niacin.
trying to see if niacin contributions to many different things, and why.
because Niacin Inositol is buffered with a Methyl, making it have both Methyl Doner & Nitrogen Doner.
making it very similar to the Nitrogen that comes in rain water, exactly like DMSO/MSM as a Sulfur Doner, in the most natrual form.
the Nitrogen in the simplest form is doing is a Heterocycle scaffolding linking Methyl Carbon lattice assembly into DNA & muscles.
apparently its the Nitrogen with Carbon that builds the framework of the body tissues.
Trigonelline is Methylated Niacin, found in Fenugreek & Coffee bean.
it appears almost identical to the Niacin Inositol, excess Niacin is converted into Trigonelline.
Trigonelline reverses Sarcopenia (muscle loss).
Niacin is the smallest vitamin & most effective Nitrogen N-Donor, and just needs a CH3 Methyl attached & its basically Trigonelline.
..
Honey 70%
Castor 10%
Niacin 5%
MSM 5%
Citrus 5%
Minerals 5%
apparently health all to do with Amino Acids, instead of supplementing 20 different amino acid powders, hotrod honey to duplicate them.
its very complex biology & chemistry, but apparently its all about Amino, and not in the way science explains it, they totally missed something & its very difficult to explain.
the reason Niacin both helps & makes worse, is because its not buffered correctly, and eventually just make more inflammation.
it literally needs to be buffered onto exactly what the healthy cell wants.
the Ph significantly changes how the Nitrogen of Niacin reacts, acidic is hot flushing, alkaline is cooling calming.
but this does not apply to raw supliments in pill or powder, it seems needs this foaming reaction with the honey & MSM.
last night & this morning, what is usually a kind of slow flushing feeling threw out the day, is now a cooling & calm effect.
this was a success in transforming the flush into something that feels like its actually doing something good.
i really hate Niacin fluch, always have, but keep pushing along regardless, because something kept nagging me to power on.
Niacin is documented to be drastically altered with high Ph, and its true.
the honey was giving me a few unusual feeling symptoms, then it occured to me to match up with the target ..
nicotinamide riboside nad overdose symptoms
its identical, the side effects are a positive confirmation, on the correct path.
..
the idea that Niacin can act as a Nitrogen Donor, in the same way Betaine acts a Methyl & Glycine Donor for proto-Amino Acids, along with DMSO for Coenzyme-A & Glutathione, plus the addition of Glucose from Honey to build all the levels of Amino Acids into Protein.
the idea is to use something like Niacin just as a Nitrogen source, Betaine CH3 Methyl source replaced by Honey (C) & Oil (H).
making a complete Amino Acid repository for all biological functions.
testing Niacin with Honey, Alkaline & Castor Oil.
i want to see if the Glucose is absolutely required with Nitrogen to manufacture Amino Acids into muscle & energy metabolism.
how i figured it out was just Niacin alone knocked out my Methyl, so then tried using MSM/DMSO to Dimethyl Sulfate to replace the missing Methyl, but then that knocked out the Nitrogen from the Niacin, ultimately both are needed but a Glucose or Sugar is required to maintain the Aminos & Protein, with an Oil to make Methyl.
RE: Intercellular Homeostasis