just seems like the very exact ingredients dont require very much to do a lot, so slamming random supliments is not the correct direction.

something is blocked, and the remedy is just to unblock something, and a little goes a long way.

it also has to do with Melatonin & Serotonin metabolism, it an important part.

i did a pretty effective test using NAC, because it so close to the general formula that seems to work best, except for the single Nitrogen, found that excess NAC seems to trigger a Histamine reaction.

the best seems to be ..

NAC
Citric (or Vitamin C)

Magnesium
Potassium

Epsom Salt is so close to the correct formula, Magnesium & Sulfur (MSM).

but need Potassium & Citrate

bypassing any need for a Nitrogen, is what it appears, just needs a Citric to activate the MSM.

MSM & Minerals without Citric Acid makes skin dry from excess Alkali, so apparently skin needs to be at Ph of 5 (acidic), requiring Citric acid.

All plants vegetation & all animal protein & blood are loaded with Nitrogen, B-Vitamins are Nitrogen ect..

beginning to suspect B-Vitamin formation & metabolism is completely dependent upon MSM Sulphur & Citric Acid Cycle, along with Magnesium & Potassium for enzyme formation.