Spindle Apparatus
Mitotic Spindle
Microtubule
Fenbendazole
Benzimidazole
Mebendazole
https://en.m.wikipedia.org/wiki/Spindle_apparatus
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Mebendazole works by selectively inhibiting the synthesis of microtubules via binding to the colchicine binding site of β-tubulin, thereby blocking polymerisation of tubulin dimers in intestinal cells of parasites.
Mebendazole has an impact on mammalian cells, mostly by inhibiting polymeration of tubulin dimers, thereby disrupting essential microtubule structures such as mitotic spindle.
Mebendazole sometimes causes diarrhea, abdominal pain, and elevated liver enzymes. In rare cases, it has been associated with a dangerously low white blood cell count, low platelet count, and hair loss,[12][13] with a risk of agranulocytosis in rare cases.
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Mitosis, Focus on Calcium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247304/
Fundamentals of Cellular Calcium Signaling: A Primer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942118/
The complex nature of calcium cation interactions with phospholipid bilayers
https://www.nature.com/articles/srep38035
Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122891/
Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564294/
Combination of calcium and magnesium ions prevents substrate inhibition and promotes biomass and lipid production
https://www.sciencedirect.com/science/article/abs/pii/S2211926416300637
Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium
https://pmc.ncbi.nlm.nih.gov/articles/PMC8122334/
Renal Control of Calcium, Phosphate, and Magnesium Homeostasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491294/
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Albumin
Amino Acid
Proteins
Hydrogen
Calcium
Ions
Osmotic Balance
Osmoregulation
Glycine Betaine
This inhibition could be relieved by addition of excess free calcium, completing the circle, and demonstrating a fundamental role for calcium in cell division.
High intakes of sodium, protein and potassium has been linked to an increase in calcium excretion through the urine, feces and sweat. Large intake of caffeine increases calcium excretion and inhibits absorption of calcium.
both hydrogen ions and calcium are bound to serum albumin, when blood becomes alkalotic, the bound hydrogen ions dissociate from albumin, freeing up the albumin to bind with more calcium and thereby decreasing the freely ionized portion of total serum calcium.
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The 2-to-1 Calcium-to-Magnesium Ratio
https://www.nutritionalmagnesium.org/optimum-calcium-magnesium-ratio/
Mystery solved: Why seashells’ mineral forms differently in seawater
Century-old riddle about aragonite formation is unraveled by scientists’ atomistic simulation.
https://news.mit.edu/2015/why-seashell-mineral-forms-differently-in-seawater-0302
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Preparation method of fenbendazole
https://patents.google.com/patent/CN103242238A/en
https://en.m.wikipedia.org/wiki/Colony-stimulating_factor
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Glycan
Polyporaceae
Polysaccharide
Turkey Tail Mushroom
Coriolus Versicolor
PSP
Polysaccharide Peptide
PSK
Polysaccharide Krestin
Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592279/
Trametes versicolor (Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy
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