@mikewick77: The Elusive

so apparently Prion/Kuru is a Copper disorder, in both directions, too much & too little, Prion is specifically misfolding Copper, above all other metals elements?

Copper Disorder
Blueblood Chromosome
Mitochondria DNA Parasites

Conotoxin
Neurofilament (Fibril)
Disulfide

https://en.m.wikipedia.org/wiki/Conotoxin

https://en.m.wikipedia.org/wiki/Neurofilament

Conotoxin inside the mitochondria, Fibril grow sharp needle-like proteins, similar to Gout, Kidney Stones & Asbestos.

Potassium Citrate breaks it down.

been testing Potassium lately, it seems very effective breaking down Endogenous Noncarbonic Oxalate Acidosis.

A mature bone matrix

In order to mimic a mature bone matrix, self-assembled fibrils can be used to align a given mineral matrix. This is accomplished using a self-assembling molecule with a hydrophobic alkyl tail and a hydrophilic oligopeptide head. These molecules form micellar structures in situ, and disulfide bridges at low pH, leading to the formation and crystallization of 200 kDa polymeric nanofibrils.

Non-interfacial self-assembly of synthetic protocells

https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-023-00402-w

papers comparing Amyloid with Protocell.

Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors

Steps Towards the Formation of A Protocell: The Possible Role of Short Peptides

Deep sea vents had ideal conditions for origin of life

https://www.ucl.ac.uk/news/2019/nov/deep-sea-vents-had-ideal-conditions-origin-life

The researchers found that molecules with longer carbon chains needed heat in order to form themselves into a vesicle (protocell). An alkaline solution helped the fledgling vesicles keep their electric charge. A saltwater environment also proved helpful, as the fat molecules banded together more tightly in a salty fluid, forming more stable vesicles.

For the first time, the researchers succeeded at creating self-assembling protocells in an environment similar to that of hydrothermal vents. They found that the heat, alkalinity and salt did not impede the protocell formation, but actively favoured it.

Hijacking and Use of Host Lipids by Intracellular Pathogens

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790186/

Lipid-protein interactions modulate the conformational equilibrium of a potassium channel

https://www.nature.com/articles/s41467-020-15741-8

Membrane potential

https://www.kenhub.com/en/library/anatomy/membrane-potential

Antimicrobial activity of different sodium and potassium salts of carboxylic acid against some common foodborne pathogens and spoilage-associated bacteria

https://www.sciencedirect.com/science/article/pii/S0325754117301013

Enzymatic Formulation Capable of Degrading Scrapie Prion under Mild Digestion Conditions

https://www.sciencedirect.com/science/article/pii/S0325754117301013

A feather-degrading Bacillus licheniformis N22 keratinase has been isolated which degraded scrapie prion to undetectable level of PrPSc signals as determined by Western Blot analysis.

PHB2 Alleviates Neurotoxicity of Prion Peptide PrP106–126 via PINK1/Parkin-Dependent Mitophagy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647768/

Chronic Ethanol Consumption and Thiamine Deficiency Modulate β-Amyloid Peptide Level and Oxidative Stress in the Brain

https://academic.oup.com/alcalc/article/52/2/159/2649115?login=false

@mikewick77: The Elusive | Ecency