γ-Secretase Modulators
GSM
RO7185876
Triazolo-Azepines
Triazoloazepine
Benzodiazepine
Alprazolam
Xanax
Benzos

RO7185876 is a novel, potent and selective modulator of γ-secretase that belongs to a novel chemical class known as the triazolo-azepines

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γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin*

https://www.jbc.org/article/S0021-9258(20)67334-3/fulltext

γ-Secretase is an intramembrane aspartyl protease that cleaves the amyloid precursor protein to produce neurotoxic β-amyloid peptides (i.e. Aβ42) that have been implicated in the pathogenesis of Alzheimer disease.