@mikewick77: Transferrin Hemolytic

there is some kind of chronic disease that occurs wit long Malaria infections, acts like a virus-like symptoms, bet it both matches HIV & long Covid symptoms, and has to do with Iron & Cobalt metabolism.

Other organisms cause hemolytic anemia by producing a hemolysin (Clostridium perfringens), by stimulating an immune response (Mycoplasma pneumoniae), by enhancing macrophage recognition and hemophagocytosis, or by as yet unknown mechanisms.

Iron decrease the absorption of other drugs such as bisphosphonates (for example, alendronate), levodopa, penicillamine, quinolone antibiotics (for example, ciprofloxacin, levofloxacin), thyroid medications (for example, levothyroxine), and tetracycline antibiotics (for example, doxycycline, minocycline).

Pernicious anemia is a disease in which not enough red blood cells are produced due to a deficiency of vitamin B12.

A complication of severe chronic PA is subacute combined degeneration of spinal cord, which leads to distal sensory loss, absent ankle reflex, increased knee reflex response, and extensor plantar response.

Hematological symptoms, including hypercellular bone marrow with blastic differentiation and hypersegmented neutrophils. Pernicious anemia can cause osteoporosis and may lead to bone fractures.

For heme synthesis, transferrin transports iron to the erythroblast mitochondria, which insert the iron into protoporphyrin IX for it to become heme. Transferrin (plasma half-life, 8 days) is extruded for reutilization. Synthesis of transferrin increases with iron deficiency but decreases with any type of chronic disease.

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