B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551072/
Methionine (Met) is one of nine essential amino acids and plays a critical role in multiple biological processes, including the initiation of all eukaryotic peptide synthesis, lipid biosynthesis, and as the primary source of methyl groups utilized by DNA.
B12 deficiency can lead to defective myelin synthesis due to decreased MUT activity, which causes incorporation of abnormal fatty acids into neuronal lipids.
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism.
https://en.m.wikipedia.org/wiki/Carboxylic_acid
Esters of fatty acids are the main components of lipids and polyamides of aminocarboxylic (amino) acids are the main components of proteins.
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25.1: The Vitamin Needed for Many Redox Reactions- Vitamin B3
Prevention of lipid loss from hair by surface and internal modification
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614367/
Hair lipids are classified into eight conventional groups: fatty acids, wax esters, squalene, cholesterol, 18-methyl eicosanoic acid (18-MEA), ceramides, hydrocarbons, and triglycerides.
Since 68.5% of total fatty acids are myristic acid (C14), palmitic acid (C16) and stearic acid (C18), these lipids were analyzed in this study. The content of wax esters is approximately 20% of the total lipid content.
Amino acids are compounds that are organic which are composed of a specific side chain, carboxylic acid, and amines. These amino acids are the building blocks of protein and they make up a fifth of an individual's body.
Amines are derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by an alkyl or aryl group.
alkane is an acyclic saturated hydrocarbon.
Alkane consists of hydrogen and carbon atoms arranged in a tree structure in which all the carbon–carbon bonds are single. Alkanes have the general chemical formula CnH2n+2. The alkanes range in complexity from the simplest case of methane.
Alkane
Hydrogen
Carbon
Carboxylic Acid
Nitrogen
Ammonia
Amine
Amino Acids
Alkylamine
Arylamine
Alkylarylamine
..
just keep going in circles, every component in this process is like its own archive of complex biological compartment.
even the words are compartmentalized, not allowed to overlap into a bigger picture.
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Vitamin B
Nitrogen Heterocycles
A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221918/
Vinyl Azides as Radical Acceptors in the Vitamin B12-Catalyzed Synthesis of Unsymmetrical Ketones
https://pubs.acs.org/doi/10.1021/acs.orglett.1c03321
Nitrogen heterocycles form peptide nucleic acid precursors in complex prebiotic mixtures
https://www.nature.com/articles/s41598-019-45310-z
Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review
https://www.sciencedirect.com/science/article/abs/pii/S0045206821004533
My 37 years of working with nitrogen heterocycles and alkaloids
https://www.publish.csiro.au/ch/pdf/CH22144
Nature loves nitrogen heterocycles
https://www.sciencedirect.com/science/article/abs/pii/S004040391401939X?via%3Dihub
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Homocysteine (Sulfur)
Methylation (Nitrogen)
Hyperhomocysteinemia
Molybdenum Cofactor Deficiency
https://en.m.wikipedia.org/wiki/Hyperhomocysteinemia
https://en.m.wikipedia.org/wiki/Molybdenum_cofactor_deficiency
low-homocysteine
https://www.drbenlynch.com/low-homocysteine/
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Carbon
Carboxylic
Carboxyl
Ethanoic
Acetic
List of carboxylic acids
https://en.m.wikipedia.org/wiki/List_of_carboxylic_acids
Heterocyclic Carboxylic Acid
Prescribed drugs containing nitrogen heterocycles: an overview
https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra09198g
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979870/
Heterocyclic N-Oxides – An Emerging Class of Therapeutic Agents
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711945/
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Cyanide Poisoning
Antidote :
solution of ferrous sulfate in aqueous citric acid, and aqueous sodium carbonate.
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N-Heterocycle Polyketide
Heterocyclic N-Oxides – An Emerging Class of Therapeutic Agents
Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and procognitive activities.
Keywords: Heterocyclic N-oxides, nitric oxide mimics, bioisosteres, hypoxia, factor Xa inhibitors, coagulation cascade direct thrombin inhibitors, antichagasic agents, antimalarials
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Biotin
Pyridine
Pyrazole
Imidazole
Fenbendazole
Heterocycle
Five- and six-membered rings with two or more heteroatoms
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Heterocycle
Imidazoles
Pyrazoles
Polyphenol
Polyketide
Therapeutic Potential of Hispidin—Fungal and Plant Polyketide
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143579/
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Polyketides represent a highly diverse group of natural products with structurally intriguing carbon skeletons which are assembled from simple acyl building blocks.
What is particularly remarkable about this heterogeneous group of compounds comprising of polyethers, polyenes, polyphenols, macrolides, and enediynes is that they are mainly derived from one of the simplest building blocks available in nature: acetic acid.
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CBG Cannabigerol
Polyketide Synthase
Diterpenoid
Polyketide
Resorcinol
Phytocannabinoid
https://en.m.wikipedia.org/wiki/Cannabigerol
https://en.m.wikipedia.org/wiki/Cannabigerolic_acid
https://en.m.wikipedia.org/wiki/Polyketide_synthase
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Peppers
Capsaicin
Niacin
Nitrogen
Nicotinic Acid Activates the Capsaicin Receptor TRPV1 – A Potential Mechanism for Cutaneous Flushing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063526/
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Carbon
Nitrogen
Spice
THC-A
Tetrahydrocannabinolic Acid
CBG
Cannabigerol
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Carbon (C)
Nitrogen (N)
Cannabigerol (C)
Capsaicin (N)
Cortisol (C)
Imidazole (N)
Polyketide (C)
Heterocycle (N)
https://en.m.wikipedia.org/wiki/Cannabigerolic_acid
https://en.m.wikipedia.org/wiki/Capsaicin
https://en.m.wikipedia.org/wiki/Carnitine
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Imidazole
Pyrazole
[Fenbendazole]
Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646865/
Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654245/
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Stem Cell
Lipid Metabolism
Lipogenesis
Haematopoiesis
Fatty Acid
Beta-Oxidation
Hematopoietic Stem Cells
Intestinal Stem Cells
Cancer Stem Cells
Neural Progenitor Cells
https://en.m.wikipedia.org/wiki/Haematopoiesis
Lipid Mediated Regulation of Adult Stem Cell Behavior
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058546/
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RE: Protonation Cation/Anion