Homo Sapiens
Alpha-Enolase

Archaea
Ribonucleoprotein RNP

Immortal Cell (Cancer)
Telomerase

Biogenesis of telomerase ribonucleoproteins

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446700/

..

Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases

https://www.frontiersin.org/articles/10.3389/fmolb.2021.811106/full

Enolase (EC number: 4.2.1.11), which is an evolutionarily conserved enzyme found in archaea, eubacteria, plants, animals and humans is one of these molecules.

Acting as a phosphopyruvate hydratase in several steps of glycolysis, enolase is necessary for survival. In addition to its catalytic function, enolase has many other functions related to different biological processes.

Human enolase has been reported to play roles in many diseases, such as cancers, autoimmune disorders, infections, and ischemia. Enolase acts as a moonlighting protein in various pathogens.

Enolase is an evolutionarily conserved enzyme that has been found in almost all kingdoms, such as Archaea, Bacteria, Plantae and Animalia

However, in our studies, enolases from mycoplasmas exhibited many characteristics that are outside of the norm for enolase. First, in terms of primary structure, mycoplasma enolases have their own sequence patterns that can easily separate mycoplasma enolases from enolases of other species.