Delivering drugs with bacterial microcompartments
A happy accident
The study team said their findings indicate numerous organisms, which generate more than one type of micro-compartment, probably use an unknown mechanism to prevent negative shell protein interactions.
Bobik noted that the entire impetus of the groundbreaking discovery was an accident.
“We noticed that the inducer of the 1,2-propanediol micro-compartment repressed the ethanolamine microcompartment, when we were trying to develop a biosensor to measure vitamin B12 levels in vivo,” he said.
Almost one-fifth of bacterial genomes generate micro-compartments, and nearly 40 percent of those contain genes for multiple micro-compartments.
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Vaults
Cells build huge vault containers constructed of a symmetric arrangement of many subunits
https://pdb101.rcsb.org/motm/114
The McdAB system positions α-carboxysomes in proteobacteria
https://onlinelibrary.wiley.com/doi/10.1111/mmi.14708
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Carboxysomes are protein-based organelles essential for carbon fixation in cyanobacteria and proteobacteria.
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Pyrenoid Plasmin Plastid Plasmid
Plastid
Cyanobacteria
https://en.m.wikipedia.org/wiki/Plastid
https://en.m.wikipedia.org/wiki/Cyanobacteria
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Bacterial Microcompartments (BMC)
Symmetrical Shell Vaults
78 identical chains
cytoplasm
Vaults ribonucleoprotein particles involved in a diversity of cellular processes, with promising applications as nanodevices for delivery of multiple cargos.
S. Tanaka, C. A. Kerfeld, M. R. Sawaya, F. Cai, S. Heinhorst, G. C. Cannon and T. O. Yeates (2008) Atomic-level models of the bacterial carboxysome shell. Science 319, 1083-1086
W. Berger, E. Steiner, M. Grusch, L. Elbling and M. Micksche (2009) Vaults and the major vault protein: novel roles in signal pathway regulation and immunity. Cellular and Molecular Life Sciences 66, 43-61.
Biogenesis of a Bacterial Organelle: The Carboxysome Assembly Pathway
https://www.cell.com/fulltext/S0092-8674(13)01362-7
Engineering Nanoreactors Using Bacterial Microcompartment Architectures
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899066/
Symmetry disruption commits vault particles to disassembly
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827651/
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Lab Origin Pathogen Round Table Dr. Johanna Dienert, Dr Jonathan Couey, Charles Rixey, Nick (HIV Researcher), Dr. Kevin W. McCairn
Biological Teleporter Could Seed Life Through Galaxy
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https://en.m.wikipedia.org/wiki/Ribonucleoprotein_particle
https://en.m.wikipedia.org/wiki/Heterogeneous_ribonucleoprotein_particle
https://en.m.wikipedia.org/wiki/SYNCRIP
https://en.m.wikipedia.org/wiki/Messenger_RNP
https://en.m.wikipedia.org/wiki/Stop_codon
https://en.m.wikipedia.org/wiki/Three_prime_untranslated_region
https://en.m.wikipedia.org/wiki/Sense_(molecular_biology)
Microcompartments in Prokaryotes: Carboxysomes and Related Polyhedra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC93316/
Bacteriophage-encoded virion-associated enzymes to overcome the carbohydrate barriers during the infection process
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380687/
Could SARS-CoV-2 Have Bacteriophage Behavior or Induce the Activity of Other Bacteriophages?
https://www.mdpi.com/2076-393X/10/5/708/htm
Intestinal Microbiota Promote Enteric Virus Replication and Systemic Pathogenesis
https://www.sciencedirect.com/topics/chemical-engineering/polyphenolic-compounds
Bacteriophages as New Human Viral Pathogens
RE: Icosahedron