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Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus

https://pubmed.ncbi.nlm.nih.gov/18495297/

Venom of the South American rattlesnake Crotalus durissus terrificus induces a long-lasting antinociceptive effect mediated by activation of kappa- and delta-opioid receptors.

BmK-YA, an enkephalin-like peptide in scorpion venom

https://pubmed.ncbi.nlm.nih.gov/22792309/

venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence.

Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7875911/

Voltage-gated calcium (Cav) channels, Cav1 and Cav2 mediate the high voltage-activated (HVA) calcium currents (I Ca) that orchestrate synaptic transmission in nociceptive dorsal root ganglion (DRG) neurons and are fine-tuned by opioid receptor (OR) activity.

Opiate-induced seizures: a study of mu and delta specific mechanisms

https://pubmed.ncbi.nlm.nih.gov/3015659/

Both morphine and morphiceptin produced electrical seizure activity in rats as young as 5 days after birth. The drugs produced similar seizure activity in terms of electrical morphology, observed behavior, ontogeny, threshold dose, and reversibility with small doses of naloxone. In the pharmacologic experiments, icv naloxone blocked all opiate-induced seizures.

Passage of SARS-CoV-2 in cells expressing human and mouse ACE2 selects for mouse-adapted and ACE2-independent viruses

https://www.biorxiv.org/content/10.1101/2021.12.16.473063v1

Recently Evolved Region of the “Dark Genome” Offers Clues to Treatment of Schizophrenia and Bipolar Disorder

https://scitechdaily.com/recently-evolved-region-of-the-dark-genome-offers-clues-to-treatment-of-schizophrenia-and-bipolar-disorder/

When we look outside the regions of DNA classed as genes, we see that the entire human genome can make proteins, not just the genes. We’ve found new proteins that are involved in biological processes and are dysfunctional in disorders like schizophrenia and bipolar disorder.